紫外线照射对脑血栓患者纤维蛋白溶解系统活性的影响

Influence of ultraviolet irradition on fibrinolytic system activity ofcerebral thrombosis patients

作者以紫外线（５０ｃｍ，剂量为２９８．４８ｍＷ／ｃｍ２，照射面积为１２０ｃｍ２）分别不同体表部位照射３组脑血栓患者１次，其中１组照射前静脉注射氨甲苯酸０．０５ｇ，分别观察３组照射前、照射后２ｈ血浆纤维蛋白原含量（ＰＦＬ）和优球蛋白溶解时间（ＥＬＴ），以及其中１组紫外线照射后ＰＦＬ的动态变化，结果表明，２组照射后ＰＦＬ较照射前减低；照射后ＥＬＴ比照射前缩短（Ｐ均＜０．０１）；照射部位或脑血栓病期的不同，其结果均无显著差异性（Ｐ均＞０．０５）；应用氨甲苯酸组照射后ＰＦＬ不再比照射前降低，照射后ＥＬＴ不再比照射前缩短（Ｐ均＞０．０５），实验证明，１次强红斑量紫外线局部照射能够激活脑血栓患者纤维蛋白溶解系统活性，且其激活作用不受脑血栓病期以及照射部位的影响；其作用机理推测与紫外线照射促进了组织型纤溶酶原激活物释放有关．本实验对探讨紫外线应用于脑血栓的预防和溶栓、抗凝治疗具有实用意义．

In our experiment,cerebral thrombosis (CT patients in 3 groups were irradiated by ultraviolet(UV)(50 cm, 298. 48 mW/cm2 , irradiated area was 120 cm2 )once on one different body surface position, inone of the 3 groups every patient was administered by 0.05 g p-aminomethylbenzoic acid (p-AA)before irra-diation, in order to observe separately every plasma fibrinogen level (PFL)and euglobin lytic time(ELT) be-fore irradiation and 2 h after irradiation, and PFL in one of the two groups without using P- AA at differenttime after irradiation, the result shows that in the two groups without using P-AA, every PFL or ELT after irradiation is lower or shorter than that before irradiation (all P<0.01), and that UV effect has no relation with its irradiation position or CT period(all P>0. 05); and that reduction of PFL at different time after ir-radiation shows curve; and that PFL or ELT 2 h after irradiation in the group with p- AA is not lower orshorter than that before administration any more(all P>0. 05 ). The result of our experiment indicates thatonce local UV irradiation can enhance the fibrinolytic system activity of CT patients , and that UV effect hasno relation with its irradiation position or CT period,and that its mechanism is related to that UV irradiationcan accelerate the release of tissular plasminogen activator. This experiment may play an important role forinvestigating the anti- coagulation, thrombolytic therapy and prevention to CT with UV.