摘要
本实验采用全自动快速荧光酶分析系统(IMx),用微粒子酶免疫测定法(MEIA)测定了105人血清鳞状细胞癌抗原(SCCAg)水平,其中34例肺鳞癌(SCC),26例肺非鳞癌(NSCC)患者血清SCCAg水平,以20例肺良性疾病和25例健康人为对照组。取2μg/L为正常值上限,超过此值为阳性,结果显示:血清SCCAg水平在肺SCC组(3.660±3.027μg/L)明显高于正常对照组(0.755±0.495μg/L)、肺良性疾病组(1.046±0.485μg/L)和肺NSCC组(1.724±1.406μg/L)(P<0.01)。两对照组中,无1例大于2μg/L,26例肺NSCC组中,2例(7.7%)阳性,而34例肺SCC组中,16例(47.1%)阳性。结果表明,血清SCCAg水平对肺鳞癌有较高的特异性,对肺鳞癌的诊断,鉴别诊断,特别是在肺癌的组织学分型中,区别肺鳞癌和肺非鳞癌有重要意义。
In this study, the serum level of squamous cell carcinoma antigen(SCCAg) was measured using IMx system by micropartical enzyme immunoassay(MEIA) method in 105 subjects,including 25 healthy pereons(N1), 20 benign pulmonary disease(BPD), 26 patients with non-squamous cell carcinoma(non-SCC) of lung and 34 patients with squamous cell carcinoma(SCC) of lung. The normal value of serum SCCAg level was 2μg/L in this experiment. The serum SCCAg level in patients with lung SCC (3. 660±3. 027μg/L) was much higher than that in patients with lung non-SCC(1.724±1.406μg/L P<0. 01), BPD(1.046±0. 485 μg/L, P<0.01) and N1 group (0. 755±0. 495μg/L P<0. 01). Elevated levels of SCCAg were observed in 16(47. 1%) of 34 patients with lung SCC, in 2(7.7%) of 26 patients with non-SCC and in none of the 20 BPD and N1 group. The results suggest that serum SCCAg level is a relatively specific marker for lung SCC. Its level is of important significance for diagnosis and differential diagnosis for lung SCC, especially for differentiating SCC patients from non-SCC ones.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1994年第1期58-60,共3页
Academic Journal of Second Military Medical University
关键词
肺肿瘤
鳞癌
抗原
诊断
carcinoma, squamous cell
lung neoplasms
diagnosis
patients