血清鳞状细胞癌抗原在肺鳞癌诊断中的价值

Value of the Serum Squamous Cell Carcinoma Antigen in Diagnosis of Lung Squamous Cell Carcinoma

本实验采用全自动快速荧光酶分析系统（ＩＭｘ），用微粒子酶免疫测定法（ＭＥＩＡ）测定了１０５人血清鳞状细胞癌抗原（ＳＣＣＡｇ）水平，其中３４例肺鳞癌（ＳＣＣ），２６例肺非鳞癌（ＮＳＣＣ）患者血清ＳＣＣＡｇ水平，以２０例肺良性疾病和２５例健康人为对照组。取２μｇ／Ｌ为正常值上限，超过此值为阳性，结果显示：血清ＳＣＣＡｇ水平在肺ＳＣＣ组（３．６６０±３．０２７μｇ／Ｌ）明显高于正常对照组（０．７５５±０．４９５μｇ／Ｌ）、肺良性疾病组（１．０４６±０．４８５μｇ／Ｌ）和肺ＮＳＣＣ组（１．７２４±１．４０６μｇ／Ｌ）（Ｐ＜０．０１）。两对照组中，无１例大于２μｇ／Ｌ，２６例肺ＮＳＣＣ组中，２例（７．７％）阳性，而３４例肺ＳＣＣ组中，１６例（４７．１％）阳性。结果表明，血清ＳＣＣＡｇ水平对肺鳞癌有较高的特异性，对肺鳞癌的诊断，鉴别诊断，特别是在肺癌的组织学分型中，区别肺鳞癌和肺非鳞癌有重要意义。

In this study, the serum level of squamous cell carcinoma antigen(SCCAg) was measured using IMx system by micropartical enzyme immunoassay(MEIA) method in 105 subjects,including 25 healthy pereons(N1), 20 benign pulmonary disease(BPD), 26 patients with non-squamous cell carcinoma(non-SCC) of lung and 34 patients with squamous cell carcinoma(SCC) of lung. The normal value of serum SCCAg level was 2μg/L in this experiment. The serum SCCAg level in patients with lung SCC (3. 660±3. 027μg/L) was much higher than that in patients with lung non-SCC(1.724±1.406μg/L P<0. 01), BPD(1.046±0. 485 μg/L, P<0.01) and N1 group (0. 755±0. 495μg/L P<0. 01). Elevated levels of SCCAg were observed in 16(47. 1%) of 34 patients with lung SCC, in 2(7.7%) of 26 patients with non-SCC and in none of the 20 BPD and N1 group. The results suggest that serum SCCAg level is a relatively specific marker for lung SCC. Its level is of important significance for diagnosis and differential diagnosis for lung SCC, especially for differentiating SCC patients from non-SCC ones.