去窦弓神经对大鼠离体胸主动脉松缩功能的影响

Effects of Sinoaortic Denervation on the Contraction and Relaxation of Rat Thoracic Aortae

作者比较了去窦弓神经（ＳＡＤ）和假手术大鼠胸主动脉对多种激动剂和Ａｃｈ的收缩和松弛作用。发现ＳＡＤ使内皮完整的胸主动脉对ＮＥ３×１０－７～１０－５ｍｏｌ／Ｌ的收缩反应和Ａｃｈ１０－９ｍｏｌ／Ｌ的松弛反应明显增强，可能与血管反应增敏有关：但ＳＡＤ并不显著改变胸主动脉对其他激动剂（ＰＥ，ＳＴ５８７，Ｂ－ＨＴ９２０，５－ＨＴ）的收缩反应和对Ａｃｈ１０－８～１０－４ｍｏｌ／Ｌ的松弛反应。

Effects of sinoaortic denervation(SAD) on the contraction and relaxation of rat thoracic aortae were studied. It was found that the contractile responses to norepinephrine 3×10-7～10-5 mol/L and the relaxant responses to acetylcholine 10-9 mol/L were more potent in SAD than sham-operated rat aortic rings with endothelium. suggesting that aortae were adapted to hypersensitivity after SAD. However, the contractile responses to phenylephrine, ST587, B-HT920 and 5-hydroxytryptamine and the relaxant responses to acetylcholine 10-8～10-4 mol/L were the same between SAD and sham-operated rat aortic rings.