慢性肾炎肾衰患者的HLA分型

HLA Typing in Patients with Chronic Renal Failure due to Glomerulomephritis

作者应用标准微量淋巴细胞毒试验方法，对我国南方８０例肾小球肾炎所致慢性肾衰患者和５８０例正常人进行ＨＬＡ分型。结果发现：本病与ＨＬＡ－Ａ，Ｂ抗原无显著相关，而与ＨＬＡ－ＤＲ４抗原显著相关（Ｐ＜０．００５）。慢性肾炎肾衰患者的ＤＲ４抗原频率为４８％，正常对照则为１９．８％。推测我国南方慢性肾炎肾衰患者的ＤＲ４抗原高频率与该地区的原发性ＩｇＡ肾病发病率有关。具有ＤＲ４抗原的原发性ＩｇＡ肾病预后不良，该类病人容易出现肾功能减退。

Eighty patients with chronic renal failure caused by glomerulonephritis underwent tissue typing for HLA-A,B and DR antigens by the standard method using a microlymphocytotoxicity test.There was no significant correlation between HLA-A,B antigens and this disease.However,the frequency of HLA-DR4 was 48% in the patients with chronic renal failure and 19.81% in the control group.It is statistically significant in the patients with chronic renal failure produced by glomerulonephritis (corrected P<0.05).The result of this study suggests that the high frequency of DR4 antigen in South Chinese patients with chronic renal failure is related to the increased morbility of primary IgA nephropathy in this area.The prognosis of primary IgA nephropathy with DR4 antigen is not benign and the patients with DR4 antigen is apt to cause renal function deterioration.