摘要
用食饵性高血脂及食饵性高血脂加免疫性动脉内皮损伤的方法建立兔动脉粥样硬化模型。观察到随着动脉粥样硬化病变发生，红细胞膜唾液酸含量降低而血清唾液酸含量增高，与对照组比较均有显著性差异（Ｐ＜０．０５）。动脉粥样硬化的程度与红细胞膜唾液酸含量呈显著负相关（Ｐ＜０．０１），与血清唾液酸含量呈显著正相关（Ｐ＜０．０５）。实验结果提示：红细胞膜和血清唾液酸含量的变化与动脉粥样硬化病变的形成及病损程度可能有密切关联。
The model of experimental atherosclerosis was established in rabbits by means of cholesterol-fed and cholesterol-fed combined with immunopathologic endothelial injudes,respectively.When atherosclerosis occurred the content of sialic acid(SA) on the erythrocyte membrane decreased,but that in serum increased and both of the changes had significant difference as compared with the control(P<0.05).The content of SA on erythrocyte membrane expressed significant negative correlation(P<0.01) but that of SA in serum expressed significant positive correlation(P<0.05) with the degree of atheroselerotic lesions.These results show that there is a close relationship between the contents of SA on erythrocytes and in serum and the atherosclerotic occurence and degree of the lesion.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1994年第3期236-240,共5页
Academic Journal of Second Military Medical University
关键词
唾液酸
红细胞
血清
动脉粥样硬化
兔
sialic acid
erythrocytes
serum
atheroslerosis
rabbits
