顺铂白蛋白微球肝动脉栓塞后在体内的分布

Distribution and Disposition of Cis-diaminedichloroplatinum following Albumin Microsphere Hepatic Arterial Embolization

用生物降解材料牛血清白蛋白制得顺铂微球，采用肝动脉插管术对新西兰兔实施肝动脉栓塞，以常规注射剂为对照，研究药物体内分布。结果：肝组织顺铂量在不同时间均显著高于注射剂对照组（Ｐ＜０．０１），栓塞１４ｄ肝中顺铂量仍为对照组的３．５倍：肾脏、脾、肺、心、脑等组织的药物量均低于对照组。提示顺铂微球肝动脉栓塞能显著提高靶区的药物浓度，同时减少在其他组织中的分布，并可降低药物的肾毒性及神经毒性反应。

Cis-diaminedichloroplatinum albumin microspheres(CDDP ams)were prepared using degraded material, bovine serum albumin. Distribution and disposition of platinum in vivo following hepatic arterial embolization were studied. The result demonstrated that the platinum in the liver was dramatically higher than that of the-contrastive group in different time(P<0.01).Platinum concentration was 3.5 times higher than that of the contrastive group after 14d.The platinum in the kidney, spleen,lungs, heart and brain was lower than that of the contrastive group.This suggests that embolization of hepatic artery with CDDP ams can increase the concentration of CDDP in target tissue, and decrease the distribution in other tissue,and the kidney and nervous toxicity.