摘要
本研究探讨了开发硝普钠透皮给药制剂的可能性，制备了膜控型和骨架型两种硝普钠贴膜剂，比较了不同剂型、不同处方和药库中药量对硝普钠透皮吸收的影响。在自发性高血压大鼠降压实验中，硝普钠贴膜剂（面积２ｃｍ２）敷贴后１０ｍｉｎ，血压即下降２．６７～５．３３ｋＰａ，可维持４８ｈ。硝普钠贴膜剂在临床上可能有较好的前途，值得进一步研究。
Sodium nitroprusside(SNP),a short-acting hypotensive agent,was studied to explore for transdermal route of administration.The membrane-moderated type and the adhensive diffusion controlled type patches were prepared and studied for their comparative performance evaluation in vitro and in vivo.The permeation of SNP through rat skin and hairless mouse skin was investigated.The systolic blood pressure(SBP)and its changes of SHR were observed, and the SBP was 2.67～5.33 kpa lower than that of control after application of the patches and returned to control level at 2h after removal of the patches.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1994年第4期328-332,共5页
Academic Journal of Second Military Medical University
基金
总后青年基金
关键词
硝普钠
高血压
透皮吸收
贴膜剂
sodium nitroprusside
hypertension
percutaneous absorption
