摘要
实验性呼吸窘迫综合征(RDS)兔支气管肺泡灌洗液(BALF)总磷脂,磷脂酰胆碱和磷脂酰甘油减少,白蛋白和C-反应蛋白升高,且与BALF表面张力增大相关。钌红染色见肺泡表面活性层失去连续、绒状结构,而以变性状态散落于肺泡腔。还见到纤维素阻拦肺表面活性物质(PS),使之不能向肺泡表面解聚的特殊现象。以上结果表明,PS质、量和形态结构的异常在实验性RDS发病中有重要作用;蛋白性肺泡渗出物能破坏或抑制PS的结构和功能。
In the rabbit model of experimental respiratory distress syndrome(RDS) it was found that total phospholipids, phosphotidylcholine,and phosphotidylglycerol were decreased in the bronchoalveolar lavage fluid (BALF)and the amount of albumin and C-reactive protein was increased in BALF in the RDS rabbits,which was correlated with an elevation of the surface tension of BALF.With ruthenium red staining,the continuous and velvety structure of the alveolar surface active layer of RDS animals was seen being converted into aggregated or vacuolized forms scattered in the alveolar cavity.It was also found that pulmonary surfactant was prevented by fibrin from unfolding on the alveolar surface.These findings suggest that the abnormality of the quality,quantity and morphology of pulmonary surfactant plays a critical role in the pathogenesis of RDS and the proteinous exudate of the alveoli can destroy the structure and inhibit the function of pulmonary surfactant.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1994年第2期99-102,共4页
Journal of Third Military Medical University
关键词
呼吸窘迫综合征
肺表面活性剂
兔
respiratory distrss syndrome
pulmonary surfactant
rabbit