药物对急性胆道感染大鼠的枯否氏细胞补体受体功能的影响

A study of the effects of drugs on the functions of Kupffer cell complement receptors during acute biliary infection in rats

本实验选用肝素、地塞米松、布洛芬三种药物，试图增强急性胆道感染大鼠的枯否氏细胞（ＫＣ）补体受体（ＣＲ）功能，结果显示：急性胆道感染（ＡＣ）组、地塞米松处理（ＤＴ）组动物死亡率明显高于肝素处理（ＨＴ）、布洛芬（ＩＴ）和假手术（ＳＯ）组；ＡＣ组术后４８ｈＫＣＣＲ功能持续下降，ＨＴ、ＩＴ能增强感染大鼠的ＫＣＣＲ功能；ＡＣ组肝肺组织细胞明显受损，ＫＣ变性，功能下降，ＨＴ能活化ＫＣＣＲ功能，吞噬活跃，组织受损轻，表明ＫＣＣＲ在急性胆道感染时是机体重要的防御屏障，其功能增强能减少动物死亡和减轻肝肺组织受损。小剂量的肝素是有明显的治疗作用，优于布洛芬和地塞米松。

Heparin, dexamethasone and ibuprofen were administered to the rats with acute obstructive cholangitis to observe the effects of the 3 agents on the functions of Kupffer cell complement receptors. It was found that the mortality rate was higher in the rats without any treatment and treated with dexamethasone than in those treated with ibuprofen or heparin.The functions of Kupffer cell complement receptors were drcreased in the rats without treatment but increased after the administration of ibuprofen or heparin. The Kupffer cells, the hepatocytes and the alveolar walls of the lungs were markedly damaged during acute obstructive cholangitis but the phagocytic function and number of Kupffer cells were increased and the damages on the liver and lungs were alleviated after the treatment of heparin.