急性呼吸性酸中毒时脑室内注入乙酰唑胺对（HCO3）的影响

Studies of the effect of acetazolamide on the level of bicarbonate ions of cerebrospinal fluid in acute respiratory acidosis in dogs

通过复制犬急性呼酸动物模型，动态观察动脉血和脑脊液（ＣＳＦ）酸碱变量发现，在动脉二氧化碳分压（ＰａＣＯ２）和血浆［ＨＣＯ３］分别升高为３．９９９ｋＰａ和３ｍｍｏｌ／Ｌ时，ＣＳＦ二氧化碳分压［ＰＣＯ２］升高值同血浆相似，而ＣＳＦ［ＨＣＯ３］的改变值在两组之间有显著性差异（Ｐ＜０．０１）。６ｈ时，Ｉ组（脑室注入乙酰唑胺）ＣＳＦ（ＨＣＯ３）平均升高为２．５ｍｍｏｌ／Ｌ；Ⅱ组（脑室注射等量人工模拟ＣＳＦ）

The acid and alkaline variables were dynamically observed in the arterial blood and cerebrospinal fluid(CSF)of a canine model of acute respiratory acidosis,It was found that when blood PaCO2 and plasma level of bicarbonate ions(HCO)were elevated to 3.999 kPa and 3 mmol/L respectively,the elevation of CSF PaCO2 was similar but the change of CSF HCO3was different between the 2 groups(P<0.01). In the 6th hour after injection,the average elevation of CSF HCO was 2.5 mmol/L in Group I(injection of acetazolamide into the cerebral ventricles)and 6 mmol/L in Group Ⅱ(injection of simulated CSF).The findings indicate that in acute respiratory acidosis,the origin of CSF HCO is mainly from the hydration of carbon dioxide in the brain and acetazolamide can inhibit the formation of CSF HCO. In the formation of CSF HCO,the formed H+ ions are buffered by NH3 partially.