脂质过氧化物与大鼠实验性胃癌的相关性研究

Studies of the role of lipid peroxides in the development of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats

文内报道了在甲基硝基亚硝基胍诱导实验性胃癌过程中的不同时期对大鼠血液与胃粘膜组织脂质过氧化物（ＬＰＯ）的含量进行了测定，并检测了大鼠正常胃粘膜、肠上皮化生、非典型增生和胃癌等组织中ＬＰＯ水平。发现给药４周后，血液与胃粘膜组织中ＬＰＯ含量显著大于给药前（Ｐ＜０．０５），第２８周末血液ＬＰＯ水平显著高于第２０周以前（Ｐ＜０。０５），第２８周末胃粘膜组织ＬＰＯ含量显著大于第１２周以前；发癌鼠血液中ＬＰＯ含量大于癌前病变鼠与正常鼠（Ｐ＜０．０５）；癌组织ＬＰＯ水平大干癌前病变组织和正常胃粘膜组织（Ｐ＜０．０５）。

The content of lipid peroxides (LPO) of the blood,normal gastric mucosa and that of intestinal metaplasia (IM), dysplasia and gastric cancer(GC)was determined in male Wistar rats in different intervals after the animals were subjected to develop gastric cancer with the administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). It was found that in the 4th week after the administration of MNNG. LPO in the blood and gastric mucosa was significantly higher than that of the control ( P<0. 05) and the level was increased progressively afterward until the end of the observation in the 28th week, In addition,the LPO content in the blood of the rats with GC was significantly higher than that of the rats with precancerous lesions and normal rats(P<0. 05) and that in the cancerous tissue was higher than that In the precancerous lelesions and normal gastric mucosa ( P<0. 05). These findings suggest that LPO may participate in the whole process of the development of gastric cancer induced by MNNG in rats.