P^（53）蛋白表达与膀胱癌预后关系的探讨

Study of the relationship between p53 expression and bladder cancer prognosis

我们应用免疫组织化学方法，对３４例石蜡包埋的膀胱癌组织标本Ｐ５３蛋白表达进行了检测。结果发现，３４例膀胱癌标本中有１４例Ｐ５３蛋白表达阳性，且Ｐ５３蛋白的表达与膀胱癌病理分级和临床分期密切相关。１４例Ｐ５３阳性病例膀胱癌的复发率为８５．７％，而２０例Ｐ５３阴性者膀胱癌的复发率为４５％。Ｐ５３阳性病例几乎全有淋巴结转移，明显高于Ｐ５３阴性者。提示Ｐ５３蛋白阳性病例预后较差。

The expression of p53 in 34 paraffin embedded specimens of urinary bladder cancer,was observed with immunohistochemical method.It was found that P53 was positive in 4l.2 %(14/34)of the specimens and there was a positive correlation of the overexpression of p53 with the pathological grading and clinical stage of bladder cancer.The recurrence rate of P53 positive bladder cancer,Was;85.7% while that of the negative cases was only 45%.Lymph node metastasis of p53 positive cases was more frequent than that of negative ones.It is believed that p53 positive bladder cancer has a poor prognosis.