正常孕产妇血清胃泌素浓度变化及其意义

Changes of serum gastrin concentration in pregnancy and the earlypostpartum period

作者测定了１８０例正常孕产妇血清胃泌素的浓度，并与２０例正常育龄非孕妇女进行比较。结果表明：早孕妇女血清胃泌素浓度（１９６．１２±３０．１１ｎｇ／Ｌ）明显高于正常育龄非孕妇女（７６．１３±１３．１１ｎｇ／Ｌ）（Ｐ＜０．０１）；中孕妇女血清胃泌素浓度（１８４．１１±２５．１４ｎｇ／Ｌ）比早孕者有所下降（Ｐ＞０．０５）；晚期孕妇胃泌素浓度（１２６．８７±２５．００ｎｇ／Ｌ）明显低于中孕者（Ｐ＜０．０５）；产妇血清胃泌素浓度（３０１．３２±５３．００ｎｇ／Ｌ）显著升高（Ｐ＜０．０１），为晚期孕妇的１．３倍。提示妊娠及产后妇女胃泌素释放明显增加，可能是机体为满足母儿能量需要的一种生理代偿作用。

Serum gastrin concentration of 180 women during pregnancy and early puerperium was determinedby radioimmunoassay and compared with that of 20 healthy nonpregnant women. Results showed that theserum gastrin concentration(196. 12±30. 11 ng/L)in the first trimester of pregnancy was significantly high-er than that of healthy nonpregnant women(76.13±13.11 ng/L)(P<0.01), and was slightly higher thanthat in the second trimester of pregnancy (184. 11±25. 14 ng/L)but with no statistical significance(P>0.05). The mean serum gastrin concentration in the third trimester of pregnancy(126.87±25.00 ng/L) waslower than in the second trimester of pregnancy(P<0.01);the mean serum gastrin concentration at the 3rdto 5th days postpartum(301.32±53.00 ng/L)was significantly increased. The results suggest that the sig-nificant increase in concentration of serum gastrin during pregnancy and early postpartum period may serve asa kind of physiologic compensatory effect of the organism to satisfy the increased need of energy of both themother and the infant.