六甲氧苄嗪对大鼠器官局部血流量的影响

Effects of hexametazidine on regional blood flow of organ in rats

作者用５１Ｃｒ标记的蛙红细胞作为放射活性生物微球，测定了六甲氧苄嗪（ＨＭＺ）对正常麻醉大鼠各器官局部血流的影响。结果表明，ＨＭＺ０．５和４．０ｍｇ／ｋｇ能明显增加心脏［１３．８±３．１ｖｓ４．２±０．９ｍｌ／（ｇ·ｍｉｎ），Ｐ＜０．０１］和脑［２．９±０．４ｖｓ０．８６±０．４ｍｌ／（ｇ·ｍｉｎ），Ｐ＜０．０１］组织的血流量，肝及肾脏次之，对骨骼肌血流无显著影响。在本实验所用剂量下，ＨＭＺ对脑血管的扩张作用优于硝苯吡啶。提示该药对心脑缺血性疾病可能有效．

Cr-labelled frog red blood cells are used to study regional blood flow of organs in anesthetizedadult rats. The results indicated that hexametazidine(HMZ)0.5,4.0mg/kg can greatly increase the bloodflow of heart [13.8±3.1 vs 4.2±0.9 ml/(g·min),P<0.01] and brain[2.9±0.4 vs 0.86±0.4ml/(g·min),P<0. 01], secondary liver and kidney and without skeletal muscle. The effects of HMZ on blood ves-sel of brain is superior to that of Nif. The experimental could indicate that HMZ is of great value in treatingthe ischemic disease of heart and brain.