dl-15-甲基前列腺素F_(2α)合并D-18-甲基三烯炔诺酮(R_(2323))抗早孕的胎盘形态学观察

A MORPHOLOGICAL STUDY ON PLACENTA AT TERMINATION OF EARLY PREGNANCY BY ADMINISTRATION OF LONG-ACTING DL-15-METHYL PROSTAGLANDIN F_(2α) IN COMBINATION WITH R_(2323)

临床分别以dl-15甲基前列腺素F_(2α)合并R_(2323)(下称PGF_(2α)+R_(2323),dl-15甲基前列腺素F_(2α)(下称PGF_(2α))和R_(2323)用于抗早孕。本文对用药后流产的早期胎盘组织进行了肉眼和光镜的观察。结果发现主要改变在壁蜕膜,包括变性、坏死、充血、出血和水肿。PGF_(2α)+R_(2323)组和PGF_(2α)组蜕膜的改变显著。R_(2323)组改变不显著。蜕膜改变的显著程度与抗早孕成功率的高低是相一致的。PGF_(2α)+R_(2323)组抗早孕成功率较高(97.93%)可能是通过两药的协同作用所致。

Long-acting dl-15-methyl PGF_(2α) in combination with R_(2323) was given for termination of early pregnancy. The gross and microscopical changes of placenta after abortion by administration of PGF_(2α) with R_(2323), PGF_(2α) and R_(2323) were observed. The changes of placenta are most obvious in decidua parietalis including degeneration, necrosis, engorgement, hemorrhage and edema. These changes are manifest in the groups of PGF_(2α) with R_(2323) and PGF_(2α), whereas less obvious in the group of R_(2323). The changes of decidua, obvious or not, are parallel to the rate of anti-early pregnacy rate. The high successful rate (97.93%) of anti-early pregnancy of PGF_(2α) with R_(2323) group may be the result of the synergistic action of these two drugs.