实验性脑损伤后体液平衡调节激素的变化及意义

The Changes and significance of ANP,AVP and Ang Ⅱin plasmafollowing experimental brain injury

目的：探讨脑损伤后心房钠尿肽（ＡＮＰ），精氨酸加压素（ＡＶＰ）及血管紧张素Ⅱ（ＡｎｇⅡ）与创伤性脑水肿的关系．方法：通过实验性大鼠脑损伤模型，利用放免法检测了脑损伤后１周内血浆ＡＮＰ，ＡＶＰ，ＡｎｇⅡ含量，同时观察脑含水量变化．结果：脑损伤后６～２４ｈ血浆ＡＮＰ减少．４８～７２ｈ明显增多；ＡｎｇⅡ于伤后１周内均明显高于正常和（或）对照组；而ＡＶＰ只于伤后２４ｈ明显高于正常和对照组．伤后７２ｈ内脑含水量明显增多，但于１周后恢复正常．结论：脑损伤后ＡＮＰ，ＡＶＰ，ＡｎｇⅡ的不同变化及相互间的功能平衡失常，可能与脑水肿的发生与发展有关．

Objective:The study was designed to observe the relationship between atrial natriuretic peptide (ANP),arginine vasopressin(AVP)and angiotensinⅡ(Ang Ⅱ)in plasma of traumatic brain edema.Meth-ods:By using radioimmunoassay,the contents of ANP,AVP and Ang Ⅱ in plasma as well as the brain water contents were measured in the rats within 7 d following brain injury.Results:The ANP decreased within 6～24 h following injury,but increased significantly within 48～72 h;Ang Ⅱ increased significantly as compared with the normal/or control groups within one week while AVP increased significantly only 24 h after brain in-jury.The brain water contents increased significantly within 72 h after injury and then gradually decreased to normal level after one week.Conclusions:The results suggested that the development of traumatic brain ede-ma might be related to the changes of ANP,AVP and Ang Ⅱ in plasma.