降钙素基因相关肽对大鼠主动脉、门静脉舒张作用的机理探讨

The diastolic mechanism of calitonin gene-related peptide on arotaand portal vein in rats

作者观察了降钙素基因相关肽（ＣＧＲＰ）对离体大鼠主动脉、门静脉的舒张效应和内皮细胞的关系．实验证明ＣＧＲＰ对大鼠主动脉舒张效应依赖于内皮细胞的存在，而门静脉的舒张效应则与内皮细胞无关．ＣＧＲＰ的舒张血管效应与Ｍ受体、α受体、前列腺素无关，提示ＣＧＲＰ的舒血管作用可能是对血管的直接抑制作用．

Relationship between the diastolic effects of calcitonin gene-related peptide(CGRP)and degree ofendothelium dependence was discussed on rat aorta and portal vein in present study. The results showed thatthe diostolic effect of aortic artery relied on the existence of endothelium, but the diastolic response of portalvein was independent on endothelium. The diastolic effect on blood vessel beared no relationship to M-recep-tor,α-receptor and prostaglandin. These suggest a possible inhibitory effect of CGRP directly on blood ves-sels.