摘要
采用硬膜外落体撞击造成SD大鼠左顶叶外伤性脑水肿模型。以伊文思蓝观察脑水肿时血脑屏障改变,探讨了不同剂量甘露醇对脑水肿的疗效与血脑屏障(BBB)的关系。结果表明:外伤性脑水肿时BBB受损害;甘露醇对正常脑组织无明显脱水作用,而对BBB受损害的水肿脑组织有明显的脱水作用。这揭示,BBB对甘露醇脱水作用具有重要影响。
rain injury on the left parietal region of SD rat was
induced by a dropping metal-weight. The changes of blood-brain barrier wasstudied by using
Evans’blue. Different dosages of mannitol were employed for the treatment of cerebral
edema. The relationship be-tween the effect of mannitol on the cerebral edema and BBB was
investigated in this experiment. The results showed that the disrup- tion of BBB was produced
in cerebral edema. Dehydration by mannitol on the normal areas of brain tissue was not
evident. But manni- tol showed better effect in the edema region,where the BBB was disrupted
after brain injury. The results suggest that BBB might bean important factor influencing the
dehydration effect of mannitol.
出处
《第一军医大学学报》
CSCD
1994年第1期30-31,共2页
Journal of First Military Medical University
关键词
脑损伤
血脑屏障
甘露醇
鼠
brain injury
blood-brain barrier
mannitol
rats