由糠醛合成铁螯合剂1－烷基－2－乙基－3－羟基吡啶－4－酮

Synthesis of the iron chelator 1-alky1-2-ethy1-3-hydroxypyridin-4-ones from furaldehyde

羟基吡啶酮类化合物是一类新型的铁螯合剂，我们以糠醛为起始原料，与溴乙烷的格氏试剂加成，水解得α－乙基呋喃甲醇（Ａ）；Ａ经氯氧化重排反应制得２－乙基－３－羟基吡喃－４－酮（Ｂ）；Ｂ与胺反应合成出１－烷基－２－乙基－３－羟基吡啶－４－酮。产物结构均经ＩＲ，ＮＭＲ光谱鉴定。

Hydroxypyridinone compounds are novel iron-chelating agents, Furaldehyde as starting material was added with Grigard’s reagent of ethyl bromide and hydrolyzed getting α-ethylfurfuryl alcohol (A). Treatment of A with chlorine forms 2-ethyl-3-hydrox-ypyran-4-one (B). Reaction of B with appropriate amine reagents by refluxing produces the iron chelator,1-alkyl-2-ethyl-3-hydrox-ypyridine-4-ones. The structure of the desired compound was identified by and ′H NMR analysis.