洗必泰醋酸盐和洗必泰葡萄糖酸盐的杀精子效果及阻抑精子对宫颈粘液穿透力的比较研究

COMPARISON OF THE ACTIVITY OF IMMOBOLIZING HUMAN SPERM AND INHIBITING ITS PENETRATION THROUGH CERVICAL MUCUS BETWEEN CHLORHEXIDINE DIGLUCONATE AND CHLORHEXIDINE DIACETATE

本文比较了洗必泰醋酸盐和洗必泰葡萄糖酸盐的杀精子效力和阻抑人精子穿透动情期牛宫颈粘液的作用。结果表明,两种形式的洗必泰盐类均有良好的杀精子效力和阻止精子穿透牛宫颈粘液的作用。应用Sander-Cramer杀精子试验法测定洗必泰醋酸盐和洗必泰葡萄糖酸盐的最低杀精子浓度分别为2.5mg/ml,5.0mg/ml。应用Cremer′s精子穿透法测定两种洗必泰盐类阻止人精子穿透牛宫颈粘液的作用很相似,当药物浓度是0.25%或0.5%时人精子穿透牛宫颈液的距离是0mm(对照是48mm)。

We compared the spermicidal potency and the inhibition of human sperm penetration through bovine oestrous cervical mucus activity between chlorhexidine digluconate and diacetate by Sander-Cramer test and Cremer's test. Both of them possessed good spermicidal activity and the capability to inhibit human sperm penetrating through bovine oestrous cervical mucus.The minimun concentration spermicide activity needed for was respectively 2.5 mg/ml for chlorhexidine diacetate and 5.0 mg/ml for chlorhexidine digluconate. The result of inhibiting human sperm penetration cervical mucus activity was very similar for two types of salt of chlorhexidine. When the concentration of chlorhexidine drug was 0.25% or 0.5%, the distance of sperm penetration accounted only approximately for 0 mm, while the control was 48 mm.Chlorhexidine is a widely used bacteriostatic antiseptic. If chlorhexldine is able to be efficacy as a spermicidal agent in the future, it may become a new type of vaginal contraceptive.