棉酚对人类红细胞Na^+、K^+跨膜流动的影响

EFFECTS OF GOSSYPOL Na^+ AND K^+ TRANSMEMBRANE FLUXES IN HUMAN RED CELLS

本文研究了男性避孕药棉酚对人类红细胞Na^+、K^+跨膜流动的影响,并与哇巴因、速尿的作用进行了比较,发现棉酚能抑制红细胞外向(Na^+、K^+)联合转运,而对(Na^+-K^+)-ATP酶可能无明显抑制作用。此结果为阐明棉酚所致低血钾症的机制,提供了一种可能的解释。

The effect of gossypol (a male contraceptive) on transmembrane fluxes of sodium and potasium in human red cells was studied in comparison with the effect of ouabain (an inhibitor of Na^+-K^+-ATPasc) and furosemide (an inhibitor of Na^+, K^+ cotransport). It was found that gossypol might be an inhibitor of outward (Na^+, K^+) cotransport in human red cells but had no significant effect on (Na^+-K^+ )-ATPase. The result provides a new evidence for elucidating the mechanism of hypokalcmia caused by gossypol.