N-〔(二甲胺基)甲基〕丙烯酰胺合成的研究

Synthesis of N-[(dimethylamino)methyl]acrylamide

以甲醛、二甲胺盐酸盐和丙烯酰胺为原料,在弱酸性介质中,合成N-[(二甲胺基)甲基]丙烯酰胺的最佳反应条件为:甲醛、二甲胺盐酸盐和丙烯酰胺的摩尔比约为1.0:1.0:1.00,第一步反应时间1.5—2.0小时,反应温度20—25℃;第二步反应时间5小时,反应温度50—60℃,可得到总转化率为75%以上的 N-[(二甲胺基)甲基]丙烯酰胺。

The synthesis of N-[(dimethylamino)methyl]acrylamide starting from formal-dehyde,dimethylamine,HCl and acrylamide,has been studied.The optimum con-ditions are:weak acidic solution;mole ratio of formaldehyde,dimethylamine.HCl and acrylamide=1.0:1.0:1.0;the reaction time of the first step:1.5—2.0hrs.;the reaction temperature of the first step:20—25℃;the reaction time ofthe second step:5hrs.;the reaction temperature of the second step:50—60℃.Agood yield is obtained.