妊娠特异性β_1糖蛋白(SP_1)单向免疫扩散法的建立及其在围产期应用的研究

Establishment of pregnancy specific B_1 glycoprotein-single radial immunodiffusion and its use in the perinatal period

本文到用从人胎盘后血青中提取的SP_1纯品,免度家免,获得了SP_1抗血清,并建立了SP_1单向屯疫扩散去。作者用比法寸妊娠23～11孕同的正常孕扫进行了观察,建立了36～11孕妇的临界值。SP_1≤100μg/ml为异常值,SP_1值>100μg/ml为正常值,此外对高危妊艰孕扫进行了观察。我仃认为测定孕妇血青SP_1水平可做为检查胎盘功能,监护高危妊娠的一项较好的指标。

Pregnancy specific B1 glyeoprotein-single radial immunodiffusion (SP1 -SRID) was established in our laboratory. SP1 anti-serum was obtained from rabbits immunized with purified human SP1. Using SP1-SRID the authors determined 241 normally pregnant women of 28-41 gestational weeks, and established the critical values of 36-41 week's gestation, with SP1≤100μg/ ml as the abnormal and>100 μg/ml as the normal values. In addition, the critical values for high-risk pregnancies were also determined. The results showed that measurement of SP1 level in pregnant women is a very good index for detecting the placental function and monitoring high-risk pregnancies.