中药复方和某种植物分泌液对脂质过氧化的抑制作用

THE PROPERTIES OF CHM, SL AND SLIV TO INHIBIT LIPID PEROXIDATION

利用发光测量法，研究了中药复方、植物分泌液（ＳＬ）和植物分泌液复方（ＳＬＩＶ）对Ｆｅ２＋－亚麻油酸－ＢＳＡ（牛血清白蛋白）和Ｆｅ２＋－脑勺浆两个离体体系产生的脂质过氧化（ＬＰＯ）有抑制作用，抑制程度与用药浓度有关．将中药复方应用于辐照模型，结果表明７Ｇｙ的γ射线辐照后小白鼠全血硒谷胱甘肽过氧化物酶（ＳｅＧＳＨ－Ｐｘ）活性降低，恢复缓慢，脑组织脂质过氧化加剧，而事先喂饲中药复方能显著提高ＳｅＧＳＨ－Ｐｘ水平，加速其活力恢复，增强脑组织抗氧化能力；将ＳＬ和ＳＬＩＶ应用于脑缺血重灌模型，结果显示沙土鼠脑缺血重灌后全血ＳｅＧＳＨ－Ｐｘ活力下降，血浆ＭＤＡ上升，ＳｅＧＳＨ－Ｐｘ／ＭＤＡ值降低，脑组织抗氧化能力下降，而事先喂饲ＳＬ、ＳＬＩＶ上述结果正相反，能明显提高机体的抗ＬＰＯ能力．

n this paper, the capabilities of CHM,SL and SLIV to inhibit lipid peroxidation (LPO) in vitro and in vivo have been studied. In vitro,the concentration-dependent decreases of ultraweak chemiluninescence were observed when CHM, SL and SLIV were added to both Fe2+-lindenic Acid-BAS and Fe2+-Brain Homogenate system respectively.In vivo, CHM may contribute to the reinforcement and recovery of antiperoxidation abilities of γ-ray-treated mice by increasing the activity of SeGSH-Px. SL and SLIV can protect ischemic-reperfused Mongolian Gerbil against LPO injuries by enhancing the value of SeGSH-Px/MDA. CHM,SL and SLIV also can protect brain tissue against LPO in vivo, shown as lower level of brain homogenate natural or induced chemiluminescence.