氯硝安定的电分析化学特性研究

Electroanalytical Characteristics of Clonazepam

用线性扫描、循环伏安、脉冲极谱、计时库仑和计时电位等方法研究了氯硝安定的电分析化学特性。在ＰＨ７．３０的缓冲溶液申，氯硝安定在－０．５５（Ｐ：）和－１．２０Ｖ处产生两个示波极谱波．利用ｐ１可测定痕量氯硝安定。线性范围为５．０×１０－８～１．０×１０－４ｍｏｌＬ－１，检测下限为３．０×１０－９ｍｏｌ·Ｌ－１。所提出的方法用于血清中氯硝安定测定，结果满意。

The electroanalytical characteristics of clonazepam were studied by linear sweep voltammetry,cyclic voltammetry, pulse polarography, chronocoulometry and chronopotentometry. In a pH7. 30 buffer solution, clonazepam gives two sensitive polarographic waves at -0.55 (p1) and -1. 20 V. p1 was used to determine the trace amounts of the drug, the linear range being 5. 0×10-8～1. 0×10-4 mol ·L-1, and detection limit being 3. 0×10-9mol·L-1.