一阶导数差示脉冲极谱法测定氢氯噻嗪的研究

Quantitative determination of hydrochloroth-iazide by first derivative differential pulse polarog-raphy

本文研究了一阶导数差示脉冲极谱法用于氢氯噻嗪及其制剂的定量分析。在０．００２ｍｏｌ／Ｌ盐酸－０．００２ｍｏｌ／Ｌ氯化钾底液中，于０．０５０Ｖ（ｖｓ．Ａｇ／ＡｇＣｌ）处出现良好的一阶导数极谱峰，氢氯噻嗪浓度在０～６．０×１０～（－４）ｍｏｌ／Ｌ范围内，与峰高呈线性关系，检测限为４．０×１０￣（－９）ｍｏｌ／Ｌ。方法操作简便、快速、灵敏、结果准确。

The first derivative differential high-speed pulsepolarography was developed for the determination ofhydrochlorothiazide and its preparation. In a solutioncontaining 0. 002mL/L potassium chloride,therewas a very good polarographic peak at 0. 050V(vsAg/AgCl).The linear relationship between concen-tration of hydrochlorothiazide and peak height wasobtained in the concentration range of 0.0～0. 060×10￣(-4)mol/L.The determination limit is 4.0×10￣(-9)mol/L. This method is simple,rapid and sensitive.The results are accurate.