^（147）pm对小鼠中枢和外周免疫细胞的损伤及rIL－1、rIL－2的防护作用

INFURY EFFECT OF 147￣Pm ON CENTRAL AND PERIPHERAL IMMUNE CELLS IN MICE AND THE RADIOPROTECTION OF rIL-1 AND rIL-2

本文研究了重核裂变产物１４７￣ｐｍ对小鼠中枢和外周免疫细胞的辐射损伤，以及外源性白细胞介素－１（ｒＩＬ－１）和外源性白细胞介素－２（ｒＩＬ－２）对机体的防护作用。结果表明，内污染１４７￣Ｐｍ后，可明显抑制中枢免疫器官骨髓细胞和胸腺细胞及外周免疫器官脾脏Ｂ淋巴细胞的ＤＮＡ合成，细胞增殖受到抑制；ｒＩＬ－１和ｒＩＬ－２对１４７￣Ｐｍ抑制上述细胞中ＤＮＡ合成具有完全或部分的保护作用。

The purpose of the present study is to ascertain the injury effects on central andperipharal immune cells by fission product of heavy nucleus,147￣Pm and the radioprotective ef-fect of lymphokines,rIL-1 and rIL-2,on 147￣Pm-irradiated immune cells,Experimental resultsshow that internal contamination of 147￣Pm could injure the proliferation of central and periph-eral immune cells. At 2nd day after 147￣Pm irradiation,the proliferation of bone marrow cells,thymus cells as well as spleen B lymphocytes was inhibited. While the 3￣H-TdR incorporationwas depressed,it should be noted that the injury effects of 147￣Pm on proliferation of centraland peripheral immune cells was perfectly or partially restored by rIL-1 or rIL-2.Both rIL-1and rIL-2 showed radioprotective effect on central and peripheral immune cells irradiated by147￣Pm.