淋巴因子相应靶细胞的小剂量辐射效应

EFFECT OF LOW DOSE RADIATION ON THE TARGET CELLS TO LYMPHOKINES RELATED

观察了单次小剂量Ｘ射线全身照射后Ｃ５７ＢＬ／６小鼠胸腺细胞ＩＬ－１反应性和脾细胞ＩＬ－２反应性的变化。发现在１００ｍＧｙ以内的小剂量照射后，整个胸腺和脾脏的细胞数趋于增多，胸腺细胞对ＩＬ－１的反应性和牌细胞对ＩＬ－２的反应性趋于增强，体外照射ＩＬ－２依赖株ＣＴＬＬ－２细胞亦出现同样的反应趋势，但统计学处理与对照组比较均无明显差异。

The changes of reactivities of thymocyte to IL-1 and splenocyte to IL-2 were studied in C 57 BL/6 mice after whole body X-irradiation with low doses. It was found that the number of thymocyte and splenocyte was increased,the reactivities of thymocyte to IL-1 and splenocyte to IL-2 also showed a tendency to increase after X-irradiation with low doses below 100 mGy, but the increase was statisticaly not significant. There was a same effect of low dese radiation on the CTLL-2, growing dependent on IL-2, irradiated in vitro.