摘要
小鼠经９８０ｃＧｙγ射线腹部照射后，用局部肠腔扩张注入法，将被测试剂注入空肠肠腔内。于照射后第４ｄ活杀小鼠，测定注入肠段和对照肠段的肠腺存活率。结果表明：单独一种嘌呤类或嘧啶类核苷酸、核苷和碱基，同小牛胸腺ＤＮＡ一样，具有提高照射后肠腺存活率的作用。这一事实提示，外源核酸对辐射损伤细胞或机体的恢复效应，并非由于其高聚状态，而是其酶解产物作用所致。
The effect of a single post-irradiation intestinal lumen dllatation injection of one of mononucleotides, nucleosides or nucleic acid bases on intestinal crypt survival after 980 cGy abdominally γ-irradiated mice has been studied. The results showed that, any one of these nucleic acid components can produce the same enhancing effect of crypt survival as that did by polymerized calf thymus DNA.This fact suggests that, the radiorestorative effect of exogenous nucleic acids on the intestinal crypt cells depends not upon the action exerted by their highly polymerised state, but rather by their various enzymatic degradation products.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1994年第2期96-99,共4页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金
关键词
电离辐射
核酸
肠腺
放射损伤
Ionizing radiation, Nucleic acid component, Intestinal crypt survival
