磺化竹红菌乙素对小鼠肝癌细胞光敏作用研究

SULPHONATED HYPOCRELLIN B SENSITIZED PHOTODAMAGE TO ASCITIC HEPATOMA CELLS

本文首次研究了小鼠腹水肝癌细胞对于磺化竹红菌乙素（简称磺化乙素Ｓ－ＨＢ）摄取的过程，并对细胞的光敏损伤进行了初步研究。结果表明：磷化乙素在水中有较大溶解度，细胞摄取与外界溶液浓度呈相关性与乙素比较对于细胞的杀伤能力相当，也能导致细胞膜脂过氧化。

In this paper the cellular uptake of sulplionated hypocrellin (S-HB). as well as photodamage on cellular viability,lipid peroxidation and intrinsic fluorescence quenching of membrane protein was studied.It was found that S-HB suitable dissolved in aqueous solution, its cellular uptake is slower that HB. The photodamage on cellular viability both photosensitizers was close to each other, however the photosensitizers were different in physical and chemical properties. The HB photodamage target of cells was membrane, but the sulphonated HB photodamage target of cells may be part of organelles, besides the membrane. The experiments showed the sulphonated HB would be suggested as a potential advantage for photodynamic therapy of tumor in clinical application.