^(192)Ir高活性源衰变对HCT-8细胞和小鼠肿瘤LA_(795)生物效应的影响

INFLUENCE OF THE ^(192)Ir SOURCE DECAY ON BIOLOGICAL EFFECT

用不同活度１９２Ｉｒ高活性源对ＨＶＴ－８细胞及小鼠肿瘤ＬＡ７９５的生物效应进行了实验。结果表明；在源活度为３２９．３ＧＢｑ及８５．１ＧＢｑ时，ＨＣＴ－８细胞存情曲线无显著不同，与Ｘ射线照射相比，相对生物效应（０．１存活）为０．４３；小鼠肿瘤ＬＡ７９５的实验结果表用，１９２Ｉｒ高活性源的源活度为２９２．３ＧＢｑ及９６．２ＧＢｑ时生物效应无显著差异，与同期Ｘ射线照射相比，相对生物效应为０．５５－０．６０（肿瘤生长延缓）。

Biologjeal effeCt of the 192Ir high activity source on LA795 tumor of mice and HoT-8 cells have been investigated,when decay of the source aboder from 340.4 GBq to 81.4 GBq. No marked,difference was found between .the tWo cell survival cutves of HCT-8 cells and both of them compared with that of the X-ray irradiation the value of relative biological effeet (0.1 survival) wad 0.43. On the experiment of tumor LA795 of mice, whem the source power was 293;3 GBq .and96.2 GBq,no different biologyal effect can be Seen between the. two series of figuies The relative biological effect was 0.55-0.60 (tumor growth delay) when compared with those of X-ray irradiation.