血清、大肠液唾液酸测定对大肠癌的诊断价值

Detection of Sialic Acid in Serum and Colorectal Fluid and Its Significance in the Diagnosis of Colorectal Carcinoma

测定大肠癌、慢性结肠炎、结肠息肉患者血清和大肠液唾液酸（ＳＡ），与正常人血清ＳＡ比较。结果表明，结肠良性病变组与正常组血清ＳＡ浓度差异无显著性，大肠癌组血清和大肠液ＳＡ浓度显著高于其余各组，阳性率分别为５９．０９％，６８．１８％。血清ＳＡ浓度与肿瘤体积呈正相关，血清ＳＡ与大肠液ＳＡ呈正相关，而肠液ＳＡ阳性率更高。根治术后血清和大肠液ＳＡ降至正常。联合应用血清ＳＡ和癌胚抗原（ＣＥＡ）测定对大肠癌诊断的准确性可达８７．８％。

Sialic acid(SA)of colorectal carcinoma, polyps,and chronic colonitis were dectected [QH`1]both in serum and in colorectal fluid.The results showed that there was no correlation between SA concentration of colorectal benign lesions and that of normal group.However,SA concentration of colorectal-carcinoma in serum and colorectal fluid was remarkable higher than the others the positive rate was 59.09% and 68.18%respectively.SA concentration in serum was positively related to the size of tumor and the SA concentration in colorectal fluid,and SA positive rate in colorectal fluid was higher than that in serum,After radical operation.SA concentration in serum and colorectal fluid was reduced to normal level.The accuracy in the diagnosis of colorectal carcinoma was 87.8%combined with the detection of SA and CEA in Serum.