“钾异心”停搏液保护心肌的实验研究Ⅲ、改进停搏液灌注方法

An Experimental Study on Myocardial Ischemia Protection by the "Jiayixin" Cardioplegia FluidⅡ,Improved Method or Cardioplegia Fluid Perfusion

比较用稳流量法和高灌压法灌注“钾异心”停傅液对心肌保护和心脏复苏的影响。稳流量组多次灌注停搏液不产生心肌水肿；再灌注时冠脉流阻降低，流量充足；常温缺血９０ｍｉｎ再灌注３０ｍｉｎ后，ＬＶＳＰ和ｄｐ／ｄｔｍａｘ基本恢复正常。高灌压组多次灌注停搏液后产生心肌水肿；再灌注后心肌继续缺血，心肌保护效果和心脏复苏欠佳。

With stable perfusive current method or high perfusive pressure method to perfuse the 'Jiayixin' cardioplegia(containing Potassium,Verapamil and Propranolol),its effects on myocardial protection and heart resuscitation were observed and compared in this research. In the group of stable current method.no myocardial edema appeared after perfusing cardioplegia repeatedly, the coronary current resistance was reduced and the blood supply to the myocardium was sufficient during the period of the reperfusion;After 90 min of arrested ischemia at normothermia and 30 min of reperfusion of blood,the LVSP and dp/dt max of the rabbit's hearts recovered nearly to the control level before ischemia.In the group of high pressure method,myocardial edema appeared after perfusing cardioplegia repeatedly,and the blood supply to the myocardium stayed insufficient after reperfusion,Therefore,the effects of the protecting ischemic myocardium and the heart resuscitation are improved.