手性药物的化学拆分—形成和分离非对映体拆分法

The Chemical Resolution of Chiral Drugs

手性药物对映体具有不同的药理活性和不同的用途。因此,获得单一对映体的药物成为一项重要的工作。而化学拆分法作为拆分的最基本的方法应用最广泛。本文通过具体手性药物的拆分介绍了该方法的原理、应用和发展。

The enantiomer of some chiral drugs has different pharmacology activity and different applying.Now, the most important thing is to obtain one of the chiral drug enantiomers. However, the chemical resolution method is widely used to resolve chiral drugs. The paper introdeces this method's principle, applying and development by resolving some chiral drugs.