膀胱移行细胞癌癌胚抗原测定的临床意义

Clinical significance of CEA in bladder transitional cell carcinoma

本文对67例膀胱移行细胞癌(TCC)患者术前行血和尿癌胚抗原(SCEA、UCEA)测定,27例膀胱部分切除术者及5例膀胱全切除术者行术后SCEA和UCEA测定,经病理分级分期,且与正常组比较。术前Ⅰ级Ⅰ期患者SCEA、UCEA值与正常组无显著性差异,Ⅱ级Ⅱ期以上者均较正常组明显增高(P<0.01),膀胱部分切除术后各级期SCEA值与正常组无显著性差异(P>0.05),Ⅰ级Ⅰ期UCEA与正常组无差异(P>0.05),Ⅱ级Ⅱ期以上者术后UCEA值与正常组相比仍呈高度显著性差异(P<0.01),膀胱全切除术后SCEA、UCEA值恢复正常。提示,TCC行膀胱部分切除术后UCEA的监测对TCC患者的预后有重要意义。

Both SCEA and UCEA were measured in 67 patients with bladder transitional cell carcinoma and 27 postoperative patients with partial cystectomy as well as 5 with total cystectomy. The grade and stage were determined by pathology. The SCEA and UCEA in grade Ⅰ ,stage Ⅰ had no significant differences as compared with normal group,in grade Ⅱ ,stage Ⅱ and higher,the SCEA and UCEA levels had beed increased significantly (P<0. 01). After operation,the SCEA level in patients with any grade and stage and UCEA in grade Ⅰ ,stage Ⅰ had no differences,but the UCEA level in grade Ⅱ , stage Ⅱ and higher was much higher compared to normal group. The SCEA and UCEA in patients with total cystectomy returned to normal level. The results showed that the measurement of UCEA has important value in monitoring the patients who have received partial cystectomy.