原发性胃癌的细胞遗传学研究

Cytogenetic studies of sixteen primary gastric cancers

用改良的直接法分析了１６例原发性胃癌的染色体，其染色体改变可分为简单类型和复杂类型两种。简单类型只涉及１～３条染色体改变，以染色体三体为主；复杂类型涉及较多的染色体数目和结构异常。本研究结果提示８和９号染色体三体可能构成胃癌的一个细胞遗传学亚型。经常出现的结构改变为７ｑ－，３ｐ－和１ｐ－。其中７ｑ－为最一致的结构异常，可认为是胃癌重要的特征性染色体改变。

An improved method of direct chromosome preparations was performed on the cytogenetic study of 16 primary gastric carcinomas.Chromosome rearrangements in this kind of cancer may be divided into the simple and the complicated types.The simple type involves 1to 3 chromosomal changes,the most commonly observed abnormalities are trisomies.The complicated one,on the other hand,includes more chromosome numerical and structural aberrations.It is suggested that trisomies 8 and 9 may represent a cytogenetic subgroup of gastric cancer.The Structural abnormalities which occurred most frequently in gastric cancer are 7q-,3p-and 1p-,The 7q-was the most consistent change(12/16)in present and might be regarded as the characteristic chromosome rerrangement in gastric cancer.