免疫球蛋白基因超家族

Immunoglobulin Gene Superfamily

免疫球蛋白基因超家族（ＩｇＳＦ）包括很多成员，它们都参予免疫应答及免疫调节。ＩｇＳＦ的分子结构与Ｉｇ很相似，也含有Ｖ及／或Ｃ功能区。所有的ＩｇＳＦ都存在于细胞膜上，它们有识别功能，并能把免疫信号传递至细胞内。ＩｇＳＦ是当今免疫学研究的重点之一。本文的重点阐述了下列ＩｇＳＦ成员的分子结构与功能：①Ｔ及Ｂ细胞抗原受体复合体，②ＭＨＣ－Ｉ及Ⅱ类抗原，③粘附分子（ＣＤ４、ＣＤ８、ＣＤ２、ＬＦα３、ＩＣＡＭ、ＶＣＡＭ，ＰＥＣＡＭ、ＮＣＡＭ），④Ｉｇ受体（多聚Ｉｇ－Ｒ，ＦｃγＲ－Ｉ、Ⅱ、Ⅲ，ＦｃεＲ－Ｉ、Ⅱ）。本文还讨论了ＩｇＳＦ的进化。

Abstract Immunoglobulin gene superfamily(IgSF)include many members which take part in immune response and immunoregulation.The molecular structure of IgSF are similar to Ig and also contain V and/or C doniain.All of the IgSF exist on the cell membrane,they have the recognizing function and can transmit the immuno-signals into the cell.In the nowadays,the IgSF is the one of the importent aspects of the immunological study.The emphases of this review is put on the molecular structure and function of the following IgSF members:①T and B cell antigen receptor complex,②MHC-Ⅰand Ⅱ antigen,③adhesion molecule(CD4、CD8、CD2、LFα3、ICAM、PECAM、NCAM),④Immunoglobulin receptors(Poly Ig-R,FcγR-Ⅰ、Ⅱ、Ⅲ,Fcε R-Ⅰ、Ⅱ).The evolution of IgSF has discussed in this paper.