稠杂环化合物的研究（X）──3－芳基－6－苯甲酰氨基均三唑并［3，4－b］－1，3，4－噻二唑类化合物的合成及生物活性

Studies on Condensed Heterocyclic Compounds(X)──Synthesis and Biological Activities of 3-Aryl-6-benzoylamino-striazolo[3,4-b]-1,3,4-thiadiazoles

本文利用３－芳基－４－氨基－５－巯基－１，２，４－均三唑和苯甲酰异硫氰酸酯在无水丙酮中反应，得到一系列３－芳基－６－苯甲酰氨基均三唑并［３，４－ｂ］－１，３，４－噻二唑，用元素分析、ＩＲ、１ＨＮＭＲ和ＭＳ确定了其结构，提出了可能的反应机制。并对其代表产物２ｈ进行了初步的抗菌和除草实验。

S-triazolo[3,4-b]-1,3,4-thiadiazoles are fused heterocyclic derivatives showing various biological effect, such as antifungal, antibacterial, hypotensive and CNS depressant. In view of the pharmacological and synthetic interests of this kind of fused heterocycles, we investigate the reaction of 3-aryl-4-amino-5-mercapto-1,2,4-s-triazoles 1a-j with benzoyl isothiocyanate in the presence of absolute acetone and obtained a series of 3-aryl-6-benzoylamino-s-triazolo[3,4-b]-1,3,4-thiadiazoles,2a-j, whose structures were determined by elemental analysis, IR, ￣1H NMR and MS. The possible mechanism of this reaction has been suggested in the meantime.It was found that the representative compound2h has moderate herbicidal activity.