生物可降解聚磷酸酯的合成及其释药性能研究

Synthesis and Drug Release Property of Biodegradable Polyphosphate Esters

生物可降解聚磷酸酯的合成及其释药性能研究罗毅，卓仁禧，范昌烈（武汉大学化学系，武汉，４３００７２）关键词聚磷酸酯，５－氟尿嘧啶，药物控制释放高分子控制释放材料的研究、发展及其在药物制剂中的应用对提高药物的持续性和专一性研究产生了突破，通过控制释放材料...

Polyphosphate esters were synthesized by the catalytic solution polycondensation of biphenols with dichlorophosphoric acid ethyl ester,dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester,respectively.The polypliosphate esters obtained were characterized by IR,￣1H NMR and elementary analysis.The in vitro drug release of 5-fluorouracil was studied in pH 7.4 phosphate buffer solution at 37℃.