N－异丙基－O－芳基－O＇－半乳吡喃基硫代磷酰胺酯的合成、结构及生物活性

Synthesis of N-Isopropyl-O-aryl-O'-galatopyranosyl thiophosphoramidates and Their Biological Activity

报道了新型Ｎ－异丙基－Ｏ－芳基Ｏ＇－半乳吡喃糖基硫代磷酰胺酯的合成，并对有关反应进行了讨论．通过重结晶分离得到了化合物Ｎ－异丙基－Ｏ－（对－氯苯基）－Ｏ＇－半乳吡喃糖基硫代磷酰胺酯的纯异构体，单晶Ｘ射线衍射分析结果表明，此纯异构体分子中手性磷原子的构型为Ｒ。初步测定了这类化合物的除草活性及抗病活性。

The synthesis of novel N-isopropyl-O-aryl-O'-galactopyranosyl thiophosphoramidates was reported,and the conditions of the reactions were discussed.A pure isomer of N-isopropyl-O-(p-chlorophenyl)-O'-galactopyranosyl thiophosphoramidate 3_d,3d' , was obtained by recrystallization from diethyl ether-petroleum ether. The result of X-ray diffraction analysis showed that the configuration of the chiral phosphorus atom of 3_d' was of R-form.The herbicidal and antidisease activities of the title compounds were tested.