黄麻粉尘致肺纤维化的实验研究

EXPERIMENTAL STUDY OF FIBROGENIC EFFECT OF JUTE DUST ON RAT LUNG

以黄麻粉尘（游离ＳｉＯ２含量分别为９．３２％、４．４０％、０．９８％）８０ｍｇ经气管注入大白鼠肺内，于染尘后１、３、６、１２个月时处死动物，进行病理学观察及肺胶原蛋白含量测定。染尘早期，肺内为细胞性反应和肺间质肺炎样改变。染尘晚期，含游离ＳｉＯ２９．３２％的黄麻粉尘可引起细胞纤维性结节，含游离ＳｉＯ２４．４０％的黄麻粉尘可引起细支气管旁轻度纤维增生，含游离ＳｉＯ２０．９８％的黄麻粉尘仅见细胞性结节。染尘后不同时期各黄麻粉尘组肺胶原蛋白含量均较盐水对照组增加（Ｐ＜０．０５、Ｐ＜０．０１）。

Jute dust(silica 9. 32%,4.4%,0. 98% respectively)were injected intratracheally for total dose of 80mg into 3 groups of Wistar rat.Pathomorphological examination and measurement of collagen content in the lung were made at 1,3,6,12 month after the injection,In the early stage,a pulmonary macrophage response and interstitial pneumonitis were observed. In the last period, grade 3 fibrosis was observed in softening dust group(silica 9. 32%).Grade 2 fibrosis was induced by carding dust group (silica 4. 40%).Grade 1 fibrosis was found in finishing dust group(silica 0.98%). Collagen content of rat lung in the groups of jute dust increased more than the control groups (p<0.05,p<0.01).