微波辐射和12－氧－十四烷酰－法波－13－醋酸酯对二甲肼诱发小鼠大肠癌的影响

EFFECT OF 2.45 GHz MICROWAVERADIATION AND PHORBOL ESTER TPA ON DIMETHYLH YDRAZINE(DMH)-INDUCED COLON CANCER IN MICE

接触电磁辐射是否与恶性肿瘤发病率增高有关为人们所关注。本研究用２．４５ＧＨｚ微波辐射小鼠以观察其是否促进ＤＭＨ诱发的大肠癌发生。另用已知促癌剂ＴＰＡ现察其促发情况。微波辐射１０ｍＷ／ｃｍ２（ＳＡＲ＝１０－１２ｍＷ／ｇ），每天３小时，一周６天，共５个月。ＴＰＡ腹腔注射２ｍｇ／ｋｇ，每周一次共１０次。结果表明微波对肿瘤发生无影响，ＴＰＡ可促进大肠癌的发展但不影响癌的发生率。

Balb/c mice were irradiated with 2.45 GHz CW microwave at 10 mW/cm2(SAR=10-12 W/kg)3 hrs. daily, 6 days a week over a period of 5 months. DMH was injected once a week over 5 months, The tumor promoter 12-o-tetrade canoylphorbol-13-acetate (TPA) was administered once a week for 10 weeks from the third week after the initial treatment of DMH. The incidence of tumors did not differ significantly among the three test groups(group B, C and D)(p>0.25).However the tumor number, size, incidence of protuberant type and infiltrative type in tumor bearing animals were higher in group D as compared to groups B and C respectively(P<0.05). No difference was found between groups B and C(p>0.25). The study showed that 2.45 GHz MW radiation does not promote DMH induced colon cancer in young mice. TPA could accelerate colon tumor production once a tumor was initiated.