大鼠急性肾功能衰竭时血浆心钠素与血管紧张素系统的关系

RELATIONSHIP OF PLASMA ATRIAL NATRIURETIC PEPTIDE WITH RENIN-ANGIOTENSIN SYSTEM IN ACUTE RENAL FAILURE

用顺铂（ＣＰ）诱发的大鼠急性肾功能衰竭（ＡＲＦ）动物实验模型，观察在急性肾功能衰竭发展的不同阶段血浆心钠素与肾素、血管紧张素系统之间的关系。发现在ＣＰ处置后２４、４８和７２ｈ，血清肌酐水平分别为正常对照组的１．５、２．５和４倍，同时血浆心钠素水平升高到１．８、２．７和３．６倍。而血浆肾素、血管紧张素系统的活性则相反，血浆肾素在２４ｈ末为正常对照组的２．５倍降低到４８ｈ的１．６倍，并于ＣＰ处置后７２ｈ恢复到正常对照组水平。血管紧张素在２４ｈ末为正常对照组４倍，在４８ｈ末下降４１％，７２ｈ末下降５８％，这表明在急性肾功能衰竭发展过程中，体内分泌的心钠素可能是通过拮抗肾素、血管紧张素系统从而起到肾功能保护的作用。

The relationship of plasma atrial natriuretic peptide(PANP)with the renin-angiotensin system(RAS) in various developmental phases of the acute renal failure induced by cisplatin in rats were observed. It was found that after 24,48 and 72 hour the cisplatin treatment,the serum creatinine levels was elevated 1.5,2. 5 and 4 folds than the normal control respectively,and that of the PANP were elevated 1.8,2. 7 and 3.6 folds respectively at the same time. On the contrary, that of the plasma renin-angiotensin system were decreased correspondingly from 2. 5 folds at 24h to 1.6 folds at 48h and same as the normal control at 72h.The results suggest that in the development of acute renal failure the atrial natriuretic peptide secreted on vivo,could be effective in the protection of renal function by its antagonistic action to the renin-angiotensin system.