脑血管病患者血浆TXB＿2、6－Keto－PGF＿（1α）含量测定及动态观察

The Determination of Plasma TXB_2 and 6-Keto-PGF_(1αin Cerebrovascular Diseases

测定６５例脑血管病患者和１４名健康人血浆中ＴＸＢ＿２、６－Ｋｅｔｏ－ＰＧＦ＿（１α）的水平，结果脑梗塞患者血浆中ＴＸＢ＿２明显增高，６－Ｋｅｔｏ－ＰＧＦ＿（１α）明显降低；脑出血、蛛网膜下腔出血患者ＴＸＢ＿２变化不明显，６－Ｋｅｔｏ－ＰＧＦ＿（１α）明显降低；脑动脉硬化患者的ＴＸＢ＿２、６－Ｋｅｔｏ－ＰＧＦ＿（１α）均无明显变化。脑梗塞患者４８ｈ、１０ｄ、３０ｄ的动态观察结果表明ＴＸＢ＿２发病后逐渐降低，至３０ｄ时趋于正常水平，６－Ｋｅｔｏ－ＰＧＦ＿（１α）逐渐升高，至１０ｄ时趋于正常水平。提示ＴＸＡ＿２－ＰＧＩ＿２平衡失调参与脑血管病的发病，其动态变化与脑梗塞病病情发展有一定关系。

The concentration of plasma TXB_2 and 6-Keto-PGF_(1α) in 65 cases with cerebrovascular diseases and 14 normal controls were determined by RIA.The results showed that the amount of plasma TXB_2 in cerebral infarction was significantly higher than that in normal controls, whereas the amount of nlasma 6-Keto-PGF_(1α) lower. A dynamic observation of 48h,10 days and 30 days after attack of cerebral infarction demonstrated that plasma level of TXB_2 gradually decreased after 48 hours, and returned to a normal level after 30 days. These findings suggest that TXA_2-PGI_2 imbalance is involved in the pathogenesis of cerebrovascular disecanes and the changes of TXA_2 and PGI_2 imbalance is involved in the pathogenesis of cerebrovascular diseases and the release are related to the development of cerebral infarction.