摘要
在传统组织形态学观察的同时，利用骨组织形态计量学的方法，对袁氏６２１促进早期动物骨折愈合的客观指标进行定量测量。结果表明，该药具有明显的促进骨痂内血管的生长，间充质细胞向成纤维细胞、成软骨细胞以及成骨细胞分化的作用，对软骨内成骨及类骨质的形成以及钙化也有较明显的促进作用，明显优于Ｌ－多巴。这些作用可能是通过巨噬细胞及ＴＧＦ－β而起作用的。该药无毒副作用，具有较高的临床应用价值及广阔的开发前景。
Guided by the theory of Trueta,a British scholar,this experimentalstudy was intepded to observe the effect of Yuan’s 621 on the healing andrep airing of bone fractures in the early stage. Histo logical examination andthe technique of bone histomorphometry were employed for the study. The results showed that Yuan’s 621 exerts an effect of promoting thegrowth of vessels and enhancing cell differentiation. It is indicated that theimplantation of vessels and the differentiation of endotheliocyte intochondrob ast and osteoblast are the basis of osteoid production and minera-lization during bone formation.
