卡他摩拉菌在慢性阻塞性肺病患者支气管肺感染中致病性的研究

The Pathogenicity of Moraxella Catarrhalis on Broncho-Pulmonary Infection in Patients with Chronic Obstructive Pulmonary Disease

对２８７例慢性阻塞性肺病急性加重期患者痰标本进行收集、细菌培养及生化检测，符合卡他摩拉菌感染者４４例（１５．３％）。该菌感染冬春寒冷季节多见，药物敏感试验提示大多数菌株对青霉素和氨苄青霉素耐药（８３．６％及７２．１％），青霉素治疗仅１１．４％有效，故应选用对β－内酰胺酶稳定的头孢菌素、氟喹诺酮类及氨基甙类抗菌药物。

Sputum culture sample were collected from 287 patients during acute exace rbations with chronic obstructive pulmonary disease(COPD), which bacterial culture and biochemical determination for 44 patients(15.3%)conformed with Moraxella catarrhalis. This kind of bacteria in part lead to mixed infection accompanied by other kinds of bacteria, which is more common during the frigid period in winter or spring.Drug sensitive test showed that 83.6%or 72.1%of strain were drug-fast to penicillin ot ampicillin, the curative effect of penicllin was accquired in only 11.4%of patients, Cephalosporins antibiotics that is stable to β-lactamases, as well as quinolones or aminoglycosides should be choosed.