摘要
本研究应用Ｇ－显带对原发性喉鳞状细胞癌手术新鲜标本进行了直接法染色体分析。有８例能进行核型分析，其中３例在二倍体范围，５例在三倍体范围。结果提示：ｉ（８ｑ）及６ｑ－可能是喉癌的特征性改变；３ｐ－在喉癌的发生上起一定的作用。尤为重要的是：喉癌的发生倾向于单克隆起源。
To clarify the cytogenetic characteristics, chromosome changes of 33 cases of squamous cell carcinomas of larynx from fresh operation samples were analyzed with direct chromosome preparation. Metaphases were obtained from 14 cases,and detailed G-banding analyses were completed from 8 cases. Three cases of them were diploid, five cases of them were triploid.The frequent characteristic changes of chromosome were as follows:6q-(three cases),i(8q)(two cases),+8(two cases),i(5p)(one case),3p-(four cases),DM, which indicated gene amplifications, was found in case 4.
出处
《哈尔滨医科大学学报》
CAS
1994年第4期298-300,共3页
Journal of Harbin Medical University
关键词
染色体
喉肿瘤
癌
鳞状细胞
Chromosomes
Laryngeal
neoplasmas
Carcinoma
squamous cell
