转铁蛋白及α_1抗胰蛋白酶遗传多态性与几种疾病的关系

The Relationship between Some Diseases and the Genetic Polymorphisms of α_1-A and Tf

本文结合关联分析与遗传方式分析的ＡＧＦＡＰ法重新分析了几份关于α１－ＡＴ及Ｔｆ的遗传多态性与几种疾病的关联，结果显示ＰｉＭ３与几种肝疾病呈负关联，Ｔｆｃ２与ＮＩＤＤＭ及肝癌呈正关联。ＡＧＡＦＰ法分析结果不排斥Ｔｆｃ２是ＮＩＤＤＭ或肝癌的一个疾病易感基因的可能。

Based on several data sets published before,the relationship between some diseases and the genetic polymorphisms of α1-A and Tf is reexamined through the association analysis and AGFAP analysis methods. The results indicate that the P1M3 is negatively associated with several hepatic diseases and Tfc2 is positively associated with NIDDM and the hepatic cancer.The results of AGFAP analysis showed that the possibility of Tfc2 is one of the disease susceptible genes of NIDDM and hepatic cancer couldn't be exclude.