肾病综合征的血凝学研究

Study of Blood Coagulation in Patients with Nephrotic Syndrome

本文采用５项血凝指标及４项生化指标对１７例肾病综合征进行了系统的血凝学研究，并对其中１２例进行了糖皮质激素治疗前后的对照观察，阐明了多因素共同作用造成肾病综合征的高凝状态，而作为首选治疗药物的糖皮质激素可以加重这种高凝状态，促发血栓形成。

In our experiments, the blood coagulation system in 17 patients with nephrotic syndrome have been tested.Among them,12 patients have been tested again after two weeks of glucocorticosteroids treatment.The results indicated :(1)impaired endothelial cells, activated coagulation system and the low levels of antithrombin Ⅲ were the important causes that resulted in the hypercoagulable state;(2)glucocorticosteroids aggravated the hypercoagulable state.