摘要
本文测定350例维生素D缺乏性佝偻病患儿和30例正常小儿的血浆胃动素浓度.结果表明,佝偻病患儿的血浆胃动素水平756±313pg/ml明显高于正常小儿259±94pg/ml(P<0.01).胃动素是由22个氨基酸组成的多肽激素,它具有强烈刺激胃和十二肠的机械运动,并可加强回肠及结肠的运动,产生胃动素的M.细胞主要分布于十二指肠和近端回肠的粘膜中.腹泻、胰腺炎和Crohn病患者的血浆胃动素水平升高,酸化十二指肠、摄入脂肪和胃扩张可有效地刺激胃动素的释放.佝偻病患儿由于缺钙体质差,肠道局部的分泌型IgA分泌不足,常伴有腹泻.因此,佝偻病患儿的胃肠功能紊乱可能促进胃动素的释放.反过来胃动素使腹泻加剧,使肠道吸收钙磷更加减少,加剧佝偻病的发展.胃动素可能在佝偻病的发展是一种致病的因子.
Plasma motilin levels were measured with RIA in rickets of children. Results showed plasmamotilin concentrations of rickets(756±313pg/ml)were markedly higher than those of normal subjects(259±94pg/ml). Motilin is a gut hormone consisted of 22 amino acids, mainly secreted by duodenum, having strongactivities of gastrointestinal motility. Elevated motilin levels were observed in diarrhea, maldigestion and pancreatitis. Children with rickets have insufficient secretory IgA, which causes diarrhea, because of their bad constitution, due to calcium lack. Thus diarrhea in rickets may be involved in promoting the release of motilin.Conversely, motilin exacerbates diarrhea, intensifies development of rickets. We suggest that motilin may be a pathogenic factor in childhood rickets.
